Buy Tetramisole Hydrochloride CAS 5086-74-8 Online USA, UK & Global Delivery

Tetramisole HCL CAS 5086-74-8 is a well-known pharmaceutical and research compound widely used in veterinary medicine, laboratory research, and chemical synthesis. At Global Chem Market, we supply premium-grade Tetramisole Hydrochloride to customers across United States, United Kingdom, Europe, and worldwide with secure global delivery and strict quality control.

Tetramisole hydrochloride is an orally active, selective inward rectifier potassium channel agonist with an EC50 of approximately 30 µM for the Kir2.1 subunit. Tetramisole hydrochloride is also an anti-nematode agent that blocks neuromuscular transmission by non-competitive depolarization. Tetramisole hydrochloride promotes the forward transport of Kir2.1 channels, hyperpolarizes the resting potential (RP), shortens the action potential duration (APD), inhibits intracellular calcium overload and the PKA signaling pathway, and exerts anti-arrhythmic and anti-myocardial remodeling activities. Tetramisole hydrochloride can be used in cardiac electrophysiology research and research related to myocardial ischemia and heart failure.

In biomedical research, Tetramisole HCl is commonly used as an alkaline phosphatase inhibitor, suitable for inhibiting various alkaline phosphatases (such as liver, kidney, placental, bone, and tumor), but it has a weaker inhibitory effect on intestinal alkaline phosphatase. Its in vitro activity is typically in the low micromolar range, with specific values depending on experimental conditions and the type of target enzyme. In cell and animal models, Tetramisole HCl has been used to study its immunomodulatory and antiparasitic effects, and the doses or concentrations used in experiments usually depend on the experimental design and research objectives.

Uses of Tetramisole Hydrochloride

Tetramisole Hydrochloride is primarily used as an anthelmintic agent in veterinary applications for the treatment and control of parasitic worm infections. It is also utilized in biomedical and pharmaceutical research, particularly in immunological studies and enzyme inhibition research. Additionally, the compound is used as an intermediate in chemical synthesis and analytical laboratory applications.

Available Form

Tetramisole Hydrochloride is available in the form of a white to off-white crystalline powder. It is odorless, water-soluble, and supplied in securely sealed, labeled packaging to ensure stability, purity, and safe transportation. Bulk and custom packaging options are available upon request.

Side Effects

When used improperly or in excessive doses, Tetramisole Hydrochloride may cause side effects such as nausea, dizziness, headache, gastrointestinal discomfort, or mild neurological reactions. In veterinary use, overdosing may lead to temporary muscle tremors or lethargy. Proper handling, dosage control, and adherence to regulatory guidelines are strongly recommended.

Chemical Formula

• Molecular Formula: C₁₁H₁₂N₂S·HCl

• Molecular Weight: 240.75 g/mol

• CAS Number: 5086-74-8

Chemistry of Tetramisole Hydrochloride

Tetramisole Hydrochloride is a synthetic imidazothiazole derivative. Chemically, it functions by interfering with neuromuscular activity in parasitic organisms, leading to paralysis and elimination. Its hydrochloride salt form improves water solubility and stability, making it suitable for pharmaceutical and laboratory applications.

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