Buy Diphenhydramine Hydrochloride (CAS No. 147-24-0) | Buy Online in USA, UK, Australia & Europe

Diphenhydramine Hydrochloride (CAS No. 147-24-0) is a widely used first-generation antihistamine compound with well-established pharmaceutical and chemical applications. At Global Chem Market, we supply premium-grade Diphenhydramine Hydrochloride that meets stringent quality standards, ensuring consistency, purity, and performance for research and industrial requirements. We proudly distribute across the United States, the United Kingdom, Australia, and Europe.

Uses of Diphenhydramine Hydrochloride

Diphenhydramine Hydrochloride is primarily used as an antihistamine for managing allergic conditions. It is also widely utilized for its anticholinergic and sedative properties. In pharmaceutical and research settings, it is commonly applied in formulations related to allergy relief, motion sickness prevention, and sleep support products. Additionally, it is used in laboratory research and chemical synthesis where antihistaminic compounds are required.

Available Form

Diphenhydramine Hydrochloride is typically available in white to off-white crystalline powder form. It is odorless or nearly odorless and freely soluble in water and alcohol, making it suitable for pharmaceutical formulations, chemical processing, and research applications. Custom packaging and bulk supply options are available upon request at Global Chem Market.

Side Effects

While Diphenhydramine Hydrochloride is widely used, it may cause certain side effects depending on dosage and exposure. Commonly reported effects include drowsiness, dizziness, dry mouth, blurred vision, and gastrointestinal discomfort. Proper handling, accurate formulation, and adherence to recommended guidelines are essential when working with this compound in any application.

Mechanism

In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely

Dosage & Safety Information (For Formulation Guidance)

Understanding proper dosing is critical for manufacturers:

Standard Adult Dose: The typical adult Benadryl dose is 25-50 mg every 4-6 hours. The max Benadryl dose for adults should not exceed 300 mg in 24 hours.

For Sleep: The standard Benadryl dosage for adults 25 mg may be insufficient for sleep; 50 mg is commonly used as a sleep aid with Diphenhydramine.

Chemical Formula

• Molecular Formula: C₁₇H₂₁NO·HCl

• Molecular Weight: 291.82 g/mol

• CAS Number: 147-24-0

The hydrochloride salt form enhances the compound’s stability and solubility, making it suitable for pharmaceutical and industrial use.

Chemistry of Diphenhydramine Hydrochloride

Diphenhydramine Hydrochloride is a first-generation ethanolamine antihistamine that works by blocking H₁ histamine receptors. Chemically, it consists of a diphenylmethoxy group linked to a dimethylamino ethanol chain, converted into a hydrochloride salt to improve shelf life and chemical stability. Its structure contributes to both its antihistaminic activity and sedative properties, making it a versatile compound in medicinal chemistry.

Why Buy from Global Chem Market?

• High-purity, quality-assured Diphenhydramine Hydrochloride

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